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Ryan Bingham works for a Human Resources consultancy firm which specializes in termination assistance, and makes his living traveling to workplaces across the United States, conducting company layoffs and firings on behalf of employers. He also gives motivational speeches, using the analogy "What's in Your Backpack?" to extol the virtues of a life free of burdensome relationships with people as well as things. A frequent flyer, Ryan has no fixed abode, relishes his travels, and desires to become the seventh and youngest person to earn ten million frequent flyer miles with American Airlines. During his travels, he meets another frequent flyer named Alex, and they begin a casual relationship.